Design and Development of a Planetary Gearbox for Electromechanical Actuator Test Bench through Additive Manufacturing

The development and validation of prognostic algorithms and digital twins for Electromechanical Actuators (EMAs) requires datasets of operating parameters that are not commonly available. In this context, we are assembling a test bench able to simulate different operating scenarios and environmental conditions for an EMA in order to collect the operating parameters of the actuator both in nominal conditions and under the effect of incipient progressive faults. This paper presents the design and manufacturing of a planetary gearbox for the EMA test bench. Mechanical components were conceived making extensive use of Fused Deposition Modelling (FDM) additive manufacturing and off-the-shelf hardware in order to limit the costs and time involved in prototyping. Given the poor mechanical properties of the materials commonly employed for FDM, the gears were not sized for the maximum torque of the electric motor, and a secondary torque path was placed in parallel of the planetary gearbox to load the motor through a disc brake. The architecture of the gearbox allowed a high gear ratio within a small form factor, and a bearingless construction with a very low number of moving parts

Effect of ammonia stripping and use of additives on separation of solids, phosphorus, copper and zinc from liquid fractions of animal slurries

To increase the sustainable reuse of animal manure as fertiliser, in many cases suitable treatment techniques are needed to modify the composition and obtain a balanced nutrient content. This study was conducted to evaluate the best strategies to remove solids, P, Cu and Zn, using two additives Ca(OH) 2 and Al 2 (SO 4 ) 3 , in combination with an ammonia stripping process. The assessment was carried out on five type of liquid fractions derived from the mechanical separation of: raw pig slurry, pig digested slurry, pig digested slurry after ammonia stripping, pig and cattle digested slurry, pig and cattle digested slurry after ammonia stripping. After the addition of the chemicals, the liquid fractions were mixed and then separated using a static filter. The contents of total solids P, Cu and Zn were determined. The additives effectively improved separation efficiencies which depended on the type of slurry and additive used. The P separation efficiencies ranged from 72% to 93% using Al 2 (SO 4 ) 3 , and from 20 to 74% using Ca(OH) 2 . The use of Al 2 (SO 4 ) 3 always had a more consistent effect on the removal efficiencies than Ca(OH) 2 . The ammonia stripping process, reducing the alkalinity of the digested liquid fractions, facilitated a higher concentration of elements in the separated fraction. With the addition of Al 2 (SO 4 ) 3 to digestate after stripping the concentration of P, Cu and Zn in the solid fraction generally increased when compared to the same liquid fraction without stripping. The addition of Ca(OH) 2 might be effective in removing P before the stripping process with the additional benefit to raise pH and improve the ammonia removal efficiency. These findings indicate that solid-liquid separation of animal manure slurries, assisted by chemical additives and coupled with ammonia stripping, can be a viable option for improving the sustainable use of animal manure as a fertiliser

Analysis of coexistence and mutual interference between mobile and digital television systems

La creciente demanda de servicios de comunicaciones inalámbricas multimedia es un factor clave en los mercados más desarrollados. Así, las palabras de moda en las comunicaciones personales “acceso para cualquier persona, en cualquier sitio, en cualquier momento y para el servicio deseado”, implican una demanda notoria y creciente del Espectro Radioeléctrico. En este sentido, la última Conferencia Mundial de Radiocomunicaciones 2007 (CMR-07) atribuyó la parte alta de la banda UHF a las redes móviles como servicio co-primario a partir del 2015 en la Región 1, aprovechando el Dividendo Digital debido a la mayor eficiencia espectral de la TV digital con respecto a la analógica. Esto tiene el potencial de causar una interferencia perjudicial entre los sistemas de televisión y los sistemas móviles y necesita ser analizado con atención. En este artículo presentamos un estudio del problema de la interferencia co-canal en dicho escenario, proponiendo una metodología para tener en cuenta la interferencia entre una red móvil LTE y un sistema televisivo DVB-T, poniendo de relieve el comportamiento diferente de los dos radioenlaces.The ever increasing demand for multimedia wireless communication systems is a key feature of more advanced markets. The buzzwords of personal communications, meant to provide “access to anyone, anywhere, at anytime to the wanted service”, implies that radio spectrum demands are dramatically increasing in most developed markets. The last World Radiocommunication Conference (WRC-07) allocated on a co-primary basis the upper part of the UHF band to mobile services as from 2015 in Region 1, taking advantage of the Digital Dividend due to the higher spectrum efficiency of digital TV with respect to the analogue system. This will cause potentially harmful mutual interference between TV and mobile radio services, that needs to be carefully analysed. In this paper we present a study of the co-channel interference problem, proposing a methodology to take into account the mutual interference between a LTE mobile network and a DVB-T system and highlighting the different behaviour of the two radio links

Fertigation of maize with digestate using drip irrigation and pivot systems

Digestate is a nutrient-rich fertilizer and appropriate techniques are required for its application during the maize season to reduce losses and increase the nitrogen use efficiency (NUE). The performance of two different fertigation techniques (drip irrigation and pivot) were assessed using the digestate liquid fraction. A two-year field test was carried out at two different sites in Lombardy, northern Italy. At each site, fertigation with pivot (P-F, site 1) or drip (D-F, site 2) systems was compared to reference fields where the same irrigation techniques without addition of digestate were used. During the two seasons, the performance of the fertigation systems, amount of fertilizers used, soil nitrogen content, yields, and nitrogen content of the harvested plants were monitored. The digestate application averaged 5 m3/ha per fertigation event with P-F and 4.9 m3/ha with D-F corresponding, respectively, to 28 and 23 kg N/ha. Both irrigation systems were suitable for fertigation provided that the digestate was adequately filtrated. Our results suggest that fertigation with digestate, if properly managed, can be applied during the growing season up to the full amount of nitrogen required by the crop

A Systematic Review on the Effects of Botanicals on Skeletal Muscle Health in Order to Prevent Sarcopenia

We performed a systematic review to evaluate the evidence-based medicine regarding the main botanical extracts and their nutraceutical compounds correlated to skeletal muscle health in order to identify novel strategies that effectively attenuate skeletal muscle loss and enhance muscle function and to improve the quality of life of older subjects. This review contains all eligible studies from 2010 to 2015 and included 57 publications. We focused our attention on effects of botanical extracts on growth and health of muscle and divided these effects into five categories: anti-inflammation, muscle damage prevention, antifatigue, muscle atrophy prevention, and muscle regeneration and differentiation

Pharmacovigilance of calcineurin inhibitors in pediatric kidney and liver transplantation

Objetivo: Desarrollar un programa de farmacovigilancia de pacientes pediátricos trasplantados hepáticos y renales centrado en inmunosupresores calcineurínicos del Hospital de Pediatría JP Garrahan de Argentina. Métodos: Se evaluaron las reacciones adversas a medicamentos (RAM) de los pacientes pediátricos trasplantados renales y hepáticos de nuestro hospital tratados con inhibidores de calcineurina (ciclosporina y tacrolimus) por revisión retrospectiva de historias clínicas de pacientes trasplantados en 2010-2011, y análisis prospectivo por farmacovigilancia activa de trasplantados fuera de dicho período, cuyas complicaciones se hayan presentado en los ateneos semanales del Servicio de Trasplante desde marzo de 2011. Las RAM se notificaron a la autoridad sanitaria nacional. Resultados: Se analizaron un total de 59 pacientes, 28 trasplantados renales y 31 hepáticos. Se notificaron, en ambos trasplantes, 60 RAM a ciclosporina destacándose (número de casos) hipertensión arterial (19) y nefrotoxicidad (6). Asimismo, se registraron 46 RAM a tacrolimus, incluyendo hipomagnesemia (25), hipertensión (7) y nefrotoxicidad (5). El 95% y 96% de los eventos adversos a ciclosporina y a tacrolimus, respectivamente, han sido agrupados como probables o definitivos. El 70% y 98% de los eventos adversos a ciclosporina y a tacrolimus respectivamente, han sido de severidad moderada o grave. Conclusiones: Este es el primer proyecto en América Latina que propone y desarrolla el estudio cuali-cuantitativo intensivo de RAM a inhibidores de calcineurina en trasplante pediátrico renal y hepático. Es necesario estimular la notificación espontánea así como continuar el seguimiento de RAM a mediano y largo plazo para mejorar la calidad de vida del paciente trasplantado.Aim: To develop a pharmacovigilance program of calcineurin inhibitors used in pediatric renal and liver transplant patients at Hospital de Pediatría JP Garrahan, Argentina. Methods: Adverse drug reactions (ADRs) of pediatric patients with kidney and liver transplantation treated with calcineurin inhibitors (cyclosporine and tacrolimus) were evaluated by retrospective review of medical records of patients transplanted between 2010 and 2011. In addition, we carried out active pharmacovigilance since March, 2011. ADRs were reported to the National Health Authority. Results: A total of 59 patients, 28 kidney transplant and 31 liver tarnsplant patients were analyzed. In both transplants, 60 ADRs to cyclosporine were reported including (number of cases), hypertension (19) and nephrotoxicity (6). In addition, 46 ADRs to tacrolimus were registered as hypomagnesemia (25), hypertension (7) and nephrotoxicity (5). A total of 95% and 96% of the adverse events to cyclosporine and tacrolimus, respectively, were defined as probable or definitive. Lastly, 70% and 98% of the events to cyclosporine and tacrolimus respectively, have been moderately severe or severe. Conclusions: This is the first study in Latin America that developed an intensive qualitative and quantitative analysis of the ADRs to calcineruin inhibitors in pediatric kidney and liver transplant patients. Spontaneous reporting should be motivated as well as monitoring ADRs should continue in the medium and long term for improving patient's quality of life.Fil: Riva, Natalia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Caceres Guido, Paulo Arturo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Rousseau, Marcela. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Dip, Marcelo. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Monteverde, Marta. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Imventarza, Oscar. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Mato, Gabriel. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Schaiquevich, Paula Susana. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Differential expression of interferon-induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha

There have been reports of in-vitro interferon (IFN)-mediated antiviral activity against the hepatitis C virus (HCV) through microRNAs (miRNAs). The main aim of this study was to evaluate the expression of several miRNAs (miR-1, miR-30, miR-128, miR-196, miR-296) in peripheral blood mononuclear cells (PBMCs) from healthy individuals after in vitro IFN-treatment and in PBMCs from patients with chronic hepatitis C (CHC) before and 12 hours after the first injection of pegylated IFN alpha. We demonstrated that expression of these miRNAs could be recorded in PBMCs collected from healthy individuals before and after in-vitro IFN alpha treatment. Our analysis revealed that the levels of expression of all miRNAs investigated in patients with CHC were different to those in healthy individuals. When levels of the miRNAs were measured 12 hours after the first IFN injection, increases in expression levels of IFN-induced miRNAs were observed in 25-50% of patients, depending on the type of miRNA examined. No correlations were observed between HCV viral load, alanine aminotransferase status and expression of miRNA. Together these findings suggest that: (i) IFN alpha in-vitro treatment of PBMCs leads to a transcriptional induction of all miRNAs investigated; (ii) miRNAs can be induced differentially by IFN treatment in patients with HCV. Given the importance of miRNAs in defending the host against virus infections, it is possible that IFN-induced miRNAs may represent an important determinant of the clinical outcome of IFN therapy in HCV infection

Compact high-brightness and highly manufacturable blue laser modules

Blue laser diode sources have already proved to be an effective alternative for material processing, especially of high reflective materials, such as copper; now the challenge is to increase their power while improving brightness and reducing the cost-per-watt. The paper presents the development of a family of blue laser modules that, making use of the same platform and assembly lines of similar 9xx nm modules, can achieve an unprecedented combination of power, brightness, compactness and cost reduction. These modules rely on a proprietary architecture to combine a plurality of chips through spatial and polarization multiplexing, obtaining up to 100W of output power in a 100 μm fiber. Preliminary experimental results for module making use of spatial multiplexing report 35W output power in a 50 μm fiber